Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 9/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300912 | 0.80 | GAA (0.54) | CYP11B1CYP11B2MEN1CYP3A4BLM | |
| SCHEMBL4042278 | 0.80 | CYP17A1 (0.59) | CYP11B1CYP11B2MEN1CYP3A4KMT2A | |
| SCHEMBL691933 | 0.79 | CALM1 (0.48) | MEN1CYP3A4KMT2AMPO | |
| SCHEMBL727185 | 0.76 | CYP1A2 (0.62) | CYP11B1CYP11B2HRH4HRH3TBXAS1 | |
| SCHEMBL9593116 | 0.76 | MEN1 (0.55) | CYP11B1CYP11B2HRH4HRH3MEN1 | |
| SCHEMBL257969 | 0.75 | CHRNA7 (0.57) | CYP11B1CYP11B2HRH4HRH3CYP3A4 | |
| SCHEMBL1773262 | 0.75 | TBXAS1 (0.56) | CYP11B1CYP11B2HRH4HRH3MEN1 | |
| SCHEMBL10920095 | 0.75 | ALDH1A1 (0.48) | CYP11B1CYP11B2MEN1TP53CYP3A4 | |
| SCHEMBL14257669 | 0.74 | CYP1A2 (0.56) | CYP11B1CYP11B2HRH4HRH3TBXAS1 | |
| SCHEMBL8307942 | 0.74 | CYP11B1 (0.47) | CYP11B1CYP11B2HRH4HRH3TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |