Sugi Predict

Sugi Predict / Compounds / SCHEMBL7434382

SCHEMBL7434382

SCHEMBL7434382

Cc1ccc(C(C)I)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 7/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ CHRNA7 P36544 1/20 0.46
▸ ALOX5 P09917 1/20 0.39
▸ CA7 P43166 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ CA1 P00915 1/20 0.36
▸ CA2 P00918 1/20 0.36
▸ CA9 Q16790 1/20 0.36
▸ CYP19A1 P11511 1/20 0.35
▸ STAT3 P40763 1/20 0.35
▸ MEN1 O00255 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ TSHR P16473 3/20 0.33
▸ MAOA P21397 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ ALOX12 P18054 1/20 0.33
▸ MAOB P27338 1/20 0.33
▸ GRIA4 P48058 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24127908 1.00 ACHE (0.47) ACHETDP1CHRNA7ALOX5CA7
SCHEMBL2857448 0.87 ESR1 (0.38) LMNA
SCHEMBL6397086 0.79 ACHE (0.50) ACHETDP1CHRNA7ALOX5CA7
SCHEMBL14160115 0.79 ACHE (0.50) ACHETDP1CHRNA7ALOX5CA7
SCHEMBL24838557 0.79 TYR (0.46) ALDH1A1GAALMNAALOX12
SCHEMBL18700118 0.79 TYR (0.46) ALDH1A1GAALMNAALOX12
SCHEMBL19122171 0.78 CHRNA7 (0.42) ACHETDP1CHRNA7ALOX5CA7
SCHEMBL6546299 0.75 ACHE (0.53) ACHETDP1CHRNA7ALOX5CA7
SCHEMBL146509 0.75 ESR1 (0.55) ACHETDP1CHRNA7ALOX5CA7
P-Cymene SCHEMBL1143 0.75 ACHE (0.53) ACHETDP1CHRNA7ALOX5CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11839679-B2 Gamma-diketones for treatment and prevention of aging skin and wrinkles BIOSPLICE THERAPEUTICS, INC. (US) 2023-12-12 — — US disclosed
US-20220087917-A1 GAMMA-DIKETONES FOR TREATMENT AND PREVENTION OF AGING SKIN AND WRINKLES VICKERS VENTURE FUND VI PTE. LTD. (SG) 2022-03-24 — — US disclosed
EP-3798214-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2021-03-31 — — EP disclosed
US-10695328-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2020-06-30 — — US disclosed
US-20190314346-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-10-17 — — US disclosed
WO-2019174279-A1 1,2-BENZISOSELENAZOL-3(2H)-ONE AND 1,2-BENZISOTHIAZOL-3(2H)-ONE DERIVATIVES AS BETA-LACTAM ANTIBIOTIC ADJUVANTS THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2019-09-19 — — WO disclosed
US-20170273985-A1 TRICYCLIC DERIVATIVE SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2017-09-28 — — US disclosed
EP-2956459-B1 SUBSTITUTED PHENYL-HEXAHYDROPYRANO[3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS PFIZER (US) 2017-07-19 — — EP disclosed
EP-2240529-B1 NAPHTHALENE-IMIDE SEMICONDUCTOR POLYMERS BASF SE (DE) 2017-07-19 — — EP disclosed
US-20170196862-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2017-07-13 — — US disclosed
EP-2810313-B1 METHOD FOR PRODUCING AN ORGANIC SEMICONDUCTOR DEVICE BASF SE (DE) 2017-06-14 — — EP disclosed
EP-2914586-B1 BRUTON'S TYROSINE KINASE INHIBITORS PFIZER (US) 2017-04-05 — — EP disclosed
EP-2791130-B1 PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS BOEHRINGER INGELHEIM INT (DE) 2016-03-16 — — EP disclosed
WO-2015182712-A1 NOVEL TETRAHYDROPYRIDOPYRIMIDINE COMPOUND OR SALT THEREOF 大鵬薬品工業株式会社 2015-12-03 — — WO disclosed
WO-2014068527-A1 BRUTON'S TYROSINE KINASE INHIBITORS PFIZER INC. (US) 2014-05-08 — — WO disclosed
EP-2366704-B1 Inhibitors of serine proteases VERTEX PHARMA (US) 2013-10-23 — — EP disclosed
WO-2013087805-A1 PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-06-20 — — WO disclosed
EP-0771196-A4 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS LILLY CO ELI (US) 1997-09-03 — — EP disclosed
EP-0771196-A1 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1997-05-07 — — EP disclosed
WO-1996007405-A1 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1996-03-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220087917-A1 GAMMA-DIKETONES FOR TREATMENT AND PREVENTION OF AGING SKIN AND WRINKLES GLA, DGKG, DGKA ACHE 1581/4885TDP1 2010/4885CHRNA7 2651/4885
US-20190314346-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS DGAT2, MGAT2, MGAT1 ACHE 3649/4885TDP1 4127/4885CHRNA7 3260/4885
US-20170273985-A1 TRICYCLIC DERIVATIVE PDE3A, PDE2A, PDE5A ACHE 54/4885TDP1 25/4885CHRNA7 2218/4885
US-11839679-B2 Gamma-diketones for treatment and prevention of aging skin and wrinkles DGKG, DGKA, DNER ACHE 1224/4885TDP1 2013/4885CHRNA7 3608/4885
US-10695328-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors DGAT2, MGAT2, MGAT1 ACHE 3649/4885TDP1 4127/4885CHRNA7 3260/4885
US-20170196862-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1B, SLC26A4 ACHE 4738/4885TDP1 4837/4885CHRNA7 966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.