Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431658 | 0.92 | ACLY (0.49) | HTR2CSMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL5898959 | 0.89 | MMP2 (0.48) | HTR2CSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL7414533 | 0.83 | MMP13 (0.56) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL5898944 | 0.80 | MMP2 (0.54) | HTR2CSMN1; SMN2ALDH1A1KMT2AHPGD | |
| SCHEMBL8361646 | 0.77 | MMP2 (0.51) | HTR2CSMN1; SMN2ALDH1A1KMT2AHPGD | |
| SCHEMBL6572436 | 0.77 | MMP2 (0.53) | SMN1; SMN2ALDH1A1KMT2AHPGDMAPK1 | |
| SCHEMBL8363785 | 0.75 | MMP2 (0.51) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL5898961 | 0.74 | MMP2 (0.52) | SMN1; SMN2ALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8361708 | 0.74 | MMP2 (0.52) | SMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL8361686 | 0.73 | MMP2 (0.47) | SMN1; SMN2ALDH1A1LMNAKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177173-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 2002-02-06 | — | — | EP | disclosed |
| WO-2001085680-A2 | SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS | PHARMACIA CORPORATION (US) | 2001-11-15 | — | — | WO | disclosed |
| WO-2000069819-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |