Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 15/20 | 0.48 |
| ▸ | TPSG1 | Q9NRR2 | 14/20 | 0.48 |
| ▸ | TPSD1 | Q9BZJ3 | 13/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7436446 | 0.84 | TPSAB1 (0.47) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| SCHEMBL7419019 | 0.83 | MEN1 (0.52) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| SCHEMBL7554479 | 0.81 | TPSAB1 (0.53) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| SCHEMBL7424872 | 0.81 | TPSAB1 (0.53) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL7422430 | 0.80 | POLB (0.44) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| SCHEMBL7965007 | 0.80 | TPSAB1 (0.69) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| SCHEMBL7415218 | 0.79 | TPSAB1 (0.77) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| SCHEMBL7421119 | 0.79 | TPSG1 (0.69) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| SCHEMBL1669277 | 0.78 | TPSAB1 (0.40) | TPSAB1TPSG1TPSD1PRSS1PRSS2 | |
| SCHEMBL7506036 | 0.78 | TPSAB1 (0.65) | TPSAB1TPSG1TPSD1PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |