Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 15/20 | 0.69 |
| ▸ | TPSG1 | Q9NRR2 | 14/20 | 0.69 |
| ▸ | TPSD1 | Q9BZJ3 | 13/20 | 0.69 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.69 |
| ▸ | PLG | P00747 | 1/20 | 0.69 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421494 | 0.91 | TPSAB1 (0.57) | TPSAB1TPSG1TPSD1PRSS1PLG | |
| SCHEMBL7554479 | 0.86 | TPSAB1 (0.53) | TPSAB1TPSG1TPSD1PRSS1PLG | |
| SCHEMBL7421119 | 0.84 | TPSG1 (0.69) | TPSAB1TPSG1TPSD1PRSS1PLG | |
| SCHEMBL7419019 | 0.81 | MEN1 (0.52) | TPSAB1TPSG1TPSD1PRSS1PLG | |
| SCHEMBL7424872 | 0.81 | TPSAB1 (0.53) | TPSAB1TPSG1TPSD1PRSS1F2 | |
| SCHEMBL7421440 | 0.81 | TPSG1 (0.71) | TPSAB1TPSG1TPSD1PRSS1PLG | |
| SCHEMBL7415218 | 0.80 | TPSAB1 (0.77) | TPSAB1TPSG1TPSD1PRSS1PLG | |
| SCHEMBL7436458 | 0.80 | TPSAB1 (0.48) | TPSAB1TPSG1TPSD1PRSS1PLG | |
| SCHEMBL7506036 | 0.78 | TPSAB1 (0.65) | TPSAB1TPSG1TPSD1PRSS1F2 | |
| SCHEMBL7418802 | 0.78 | TPSAB1 (0.44) | TPSAB1TPSG1TPSD1PRSS1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | claimed |
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |