Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TPSAB1 | Q15661 | 7/20 | 0.50 |
| ▸ | TPSD1 | Q9BZJ3 | 7/20 | 0.50 |
| ▸ | TPSG1 | Q9NRR2 | 7/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801417 | 0.83 | MEN1 (0.55) | MEN1KMT2ASMN1; SMN2CYP2C19MAPT | |
| SCHEMBL7436458 | 0.83 | TPSAB1 (0.48) | MEN1KMT2ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7554479 | 0.82 | TPSAB1 (0.53) | MEN1KMT2AMAPTTPSAB1TPSD1 | |
| SCHEMBL7424872 | 0.82 | TPSAB1 (0.53) | MEN1KMT2ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7965007 | 0.81 | TPSAB1 (0.69) | MEN1KMT2AMAPTTPSAB1TPSD1 | |
| SCHEMBL15504601 | 0.81 | TP53 (0.55) | MEN1KMT2ASMN1; SMN2CYP2C19MAPT | |
| SCHEMBL15515225 | 0.81 | KDM4E (0.63) | MEN1KMT2ASMN1; SMN2CYP2C19HTT | |
| SCHEMBL7415218 | 0.81 | TPSAB1 (0.77) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7421119 | 0.81 | TPSG1 (0.69) | MAPTTPSAB1TPSD1TPSG1PRSS1 | |
| SCHEMBL5595635 | 0.80 | NAMPT (0.58) | MAPTNPSR1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |