Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 9/20 | 0.52 |
| ▸ | EIF4E | P06730 | 2/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5999257 | 0.88 | KDM4E (0.55) | RORCEIF4EAMY1AKDM4ENPC1 | |
| SCHEMBL25276567 | 0.87 | PKM (0.56) | PKMRORCEIF4EDHODHKDM4E | |
| SCHEMBL7440079 | 0.83 | PKM (0.47) | PKMRORCEIF4EAMY1ADHODH | |
| SCHEMBL6660568 | 0.82 | ATP4A (0.58) | DHODHKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25278857 | 0.79 | PKM (0.55) | PKMRORCDHODHKDM4E | |
| SCHEMBL2734989 | 0.78 | RAB9A (0.54) | AMY1AKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1800878 | 0.78 | ALDH1A1 (0.65) | PKMRORCAMY1AKDM4EALDH1A1 | |
| SCHEMBL7440680 | 0.78 | ABL1 (0.57) | EIF4EKDM4ENPC1RAB9A | |
| SCHEMBL7440072 | 0.77 | PKM (0.50) | PKMRORCEIF4EAMY1ADHODH | |
| SCHEMBL7432599 | 0.77 | HTR2C (0.60) | RORCEIF4EKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |