Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | EIF4E | P06730 | 9/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734989 | 0.83 | RAB9A (0.54) | ABL1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL7434501 | 0.82 | ALOX5 (0.50) | ABL1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL6664214 | 0.81 | ATP4A (0.60) | ABL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7441165 | 0.80 | CYP3A4 (0.44) | ABL1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL3452786 | 0.79 | TP53 (0.51) | ABL1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL5999524 | 0.79 | RAB9A (0.62) | KDM4EMEN1NPC1RAB9AKMT2A | |
| SCHEMBL7426301 | 0.79 | MEN1 (0.48) | ABL1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL16238595 | 0.79 | CYP3A4 (0.50) | ABL1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL7436623 | 0.78 | PKM (0.55) | KDM4ENPC1RAB9AEIF4E | |
| SCHEMBL6687941 | 0.78 | LTA4H (0.61) | KDM4EMEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |