Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | EDNRA | P25101 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437241 | 0.89 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HPGDPSMB5PSMB1 | |
| SCHEMBL8680993 | 0.88 | EDNRA (0.44) | ALDH1A1SMN1; SMN2HPGDPSMB5PSMB1 | |
| SCHEMBL8680988 | 0.88 | EDNRA (0.44) | ALDH1A1SMN1; SMN2HPGDPSMB5PSMB1 | |
| SCHEMBL7312640 | 0.86 | PSMB1 (0.44) | ALDH1A1PSMB5PSMB1PSMB2POLB | |
| SCHEMBL7303213 | 0.86 | PSMB1 (0.41) | ALDH1A1PSMB5PSMB1PSMB2POLB | |
| SCHEMBL7307063 | 0.86 | PSMB1 (0.48) | PSMB5PSMB1PSMB2CTSLCTSS | |
| SCHEMBL7304423 | 0.86 | PSMB1 (0.48) | PSMB5PSMB1PSMB2CTSLCTSS | |
| SCHEMBL7303357 | 0.85 | CTSS (0.46) | ALDH1A1PSMB5PSMB1PSMB2POLB | |
| SCHEMBL7436642 | 0.85 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HPGDPSMB5PSMB1 | |
| SCHEMBL7305805 | 0.85 | MGLL (0.38) | ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |