Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007926 | 0.85 | TSHR (0.59) | TSHRADRB2NPSR1SMN1; SMN2HTT | |
| SCHEMBL7426489 | 0.85 | CHRM2 (0.38) | TSHRSMN1; SMN2CHRM2CHRM1LMNA | |
| SCHEMBL1007435 | 0.85 | TSHR (0.59) | TSHRADRB2NPSR1SMN1; SMN2HTT | |
| SCHEMBL7434817 | 0.85 | LMNA (0.51) | TSHRNPSR1LMNA | |
| SCHEMBL1007437 | 0.85 | TSHR (0.59) | TSHRADRB2NPSR1SMN1; SMN2HTT | |
| Bromide SCHEMBL9763944 | 0.84 | TSHR (0.58) | TSHRADRB2NPSR1SMN1; SMN2HTT | |
| Bromide SCHEMBL9763950 | 0.84 | TSHR (0.58) | TSHRADRB2NPSR1SMN1; SMN2HTT | |
| SCHEMBL7431600 | 0.83 | CHRM2 (0.37) | TSHRSMN1; SMN2HTTCHRM2CHRM1 | |
| SCHEMBL7439650 | 0.83 | CHRM2 (0.56) | CHRM2CHRM1ALOX5HSD11B1LMNA | |
| SCHEMBL7278715 | 0.83 | OPRD1 (0.50) | TSHRADRB2NPSR1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |