Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 4/20 | 0.54 |
| ▸ | ATP4B | P51164 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7440874 | 0.99 | ATP4A (0.55) | ATP4AATP4BHRH3CHEK2LTA4H | |
| SCHEMBL7436848 | 0.87 | ATP4A (0.56) | ATP4AATP4BHRH3CHEK2LTA4H | |
| Hydrochloric Acid SCHEMBL7443354 | 0.86 | ATP4A (0.57) | ATP4AATP4BHRH3CHEK2LTA4H | |
| Hydrochloric Acid SCHEMBL7438235 | 0.83 | MCHR1 (0.52) | HRH3LTA4H | |
| SCHEMBL7437601 | 0.81 | ATP4A (0.54) | ATP4AATP4BHRH3LTA4HPRKAB2 | |
| Hydrochloric Acid SCHEMBL7440865 | 0.80 | ATP4A (0.55) | ATP4AATP4BHRH3LTA4HPRKAB2 | |
| Hydrochloric Acid SCHEMBL7439030 | 0.77 | MCHR1 (0.39) | ESR1ESR2 | |
| SCHEMBL3612018 | 0.77 | ACHE (0.57) | ATP4AATP4BHRH3LTA4HPRKAB2 | |
| SCHEMBL7437408 | 0.76 | ATP4A (0.58) | ATP4AATP4BHRH3LTA4HPRKAB2 | |
| SCHEMBL7435769 | 0.74 | MAPT (0.60) | ATP4AATP4BLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |