Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | ATP4A | P20648 | 4/20 | 0.53 |
| ▸ | ATP4B | P51164 | 4/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608066 | 0.81 | MCHR1 (0.46) | ACHEROCK1PRKACAATP4AATP4B | |
| SCHEMBL3613064 | 0.79 | ALDH1A1 (0.47) | ACHELTA4HHRH3CHEK1 | |
| SCHEMBL7437601 | 0.79 | ATP4A (0.54) | ACHEROCK1PRKACAATP4AATP4B | |
| SCHEMBL7436848 | 0.78 | ATP4A (0.56) | ACHEROCK1PRKACAATP4AATP4B | |
| SCHEMBL3600865 | 0.78 | MAOA (0.53) | ACHEROCK1NPC1 | |
| Hydrochloric Acid SCHEMBL7440865 | 0.78 | ATP4A (0.55) | ACHEROCK1PRKACAATP4AATP4B | |
| Hydrochloric Acid SCHEMBL7443354 | 0.77 | ATP4A (0.57) | ACHEROCK1PRKACAATP4AATP4B | |
| SCHEMBL7437613 | 0.77 | ATP4A (0.54) | ACHEROCK1PRKACAATP4AATP4B | |
| SCHEMBL13883476 | 0.76 | HRH3 (0.61) | LTA4HHRH3 | |
| Hydrochloric Acid SCHEMBL7440874 | 0.76 | ATP4A (0.55) | ACHEROCK1PRKACAATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | GRN, MAPT, GUCY1B1 | ACHE 176/4885ROCK1 550/4885PRKACA 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.