Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | PKLR | P30613 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.54 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401318 | 0.89 | SLC1A3 (0.57) | LMNAPKMPKLRSLC1A3SLC1A2 | |
| SCHEMBL4134778 | 0.84 | LMNA (0.57) | LMNAPKMPKLRSMN1; SMN2RECQL | |
| SCHEMBL4134777 | 0.84 | LMNA (0.57) | LMNAPKMPKLRSMN1; SMN2RECQL | |
| SCHEMBL6831087 | 0.83 | LMNA (0.56) | LMNAPKMPKLRSMN1; SMN2GAA | |
| SCHEMBL7348707 | 0.82 | SLC1A3 (0.61) | PKLRSLC1A3SLC1A2SLC1A1ITGB3 | |
| SCHEMBL7348701 | 0.82 | SLC1A3 (0.61) | PKLRSLC1A3SLC1A2SLC1A1ITGB3 | |
| SCHEMBL8352258 | 0.81 | SLC1A3 (0.58) | SLC1A3SLC1A2SLC1A1KDM4EITGB3 | |
| SCHEMBL7064240 | 0.81 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1KDM4EITGB3 | |
| SCHEMBL15251811 | 0.81 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1KDM4EITGB3 | |
| SCHEMBL6793418 | 0.81 | SLC1A3 (0.57) | SLC1A3SLC1A2SLC1A1KDM4EITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765340-B1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5776927-A | THROMBIN INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5681844-A | ANTITHROMBOTIC AGENTS, ANTICOAGULANTS | CORVAS INTERNATIONAL, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| US-5658939-A | PREVENTION THROMBOSIS IN MAMMALS | CORVAS INTERNATIONAL INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5646165-A | ANTITHROMBOTIC AGENTS | CORVAS INTERNATIONAL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0765340-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995028420-A1 | METHIONINE SULFONE AND S-SUBSTITUTED CYSTEINE SULFONE DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-10-26 | — | — | WO | disclosed |