Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 4/20 | 0.38 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438139 | 0.89 | P2RX7 (0.36) | P2RX7SLC6A2SLC6A4SLC6A3DOT1L | |
| SCHEMBL7434829 | 0.86 | P2RX7 (0.40) | P2RX7SLC6A2SLC6A4SLC6A3CASP1 | |
| SCHEMBL7684425 | 0.84 | CASP1 (0.38) | CASP1DOT1LCASP3MEN1ALDH1A1 | |
| SCHEMBL7432370 | 0.82 | HPGD (0.48) | CASP1LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL7677059 | 0.80 | ALDH1A1 (0.38) | CASP1LMNACASP3MEN1ALDH1A1 | |
| SCHEMBL7682128 | 0.80 | ALDH1A1 (0.38) | CASP1LMNACASP3MEN1ALDH1A1 | |
| SCHEMBL7684400 | 0.80 | CASP1 (0.39) | P2RX7CASP1DOT1LCASP3MEN1 | |
| SCHEMBL7681897 | 0.77 | ALDH1A1 (0.38) | P2RX7CASP1LMNACASP3MEN1 | |
| SCHEMBL7678219 | 0.77 | ALDH1A1 (0.36) | LMNACASP3MEN1ALDH1A1KMT2A | |
| SCHEMBL7439400 | 0.77 | CASP1 (0.48) | P2RX7SLC6A2SLC6A4SLC6A3CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |