Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438437 | 0.86 | P2RX7 (0.40) | P2RX7CASP3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7436751 | 0.82 | RAB9A (0.48) | CASP3CASP1LMNASMN1; SMN2 | |
| SCHEMBL7439400 | 0.78 | CASP1 (0.48) | P2RX7CASP3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7438139 | 0.76 | P2RX7 (0.36) | P2RX7SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL9170587 | 0.73 | P2RX7 (0.55) | P2RX7SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL7437226 | 0.72 | CASP3 (0.49) | CASP3CASP1 | |
| SCHEMBL7434554 | 0.72 | CASP1 (0.52) | CASP1 | |
| SCHEMBL7437562 | 0.72 | CASP1 (0.55) | CASP3CASP1 | |
| SCHEMBL7684425 | 0.71 | CASP1 (0.38) | CASP3CASP1DOT1L | |
| SCHEMBL7440546 | 0.70 | CASP1 (0.49) | CASP3CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | claimed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |