Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426992 | 0.91 | BPTF (0.36) | MEN1KMT2ARAB9AMAPK1L3MBTL1 | |
| SCHEMBL7434796 | 0.78 | SLC9A1 (0.41) | RAB9AIDO1METAP2ALDH1A1KDM4E | |
| SCHEMBL7440162 | 0.77 | SLC9A1 (0.41) | MEN1KMT2AIDO1KDM4EMAPT | |
| SCHEMBL9324010 | 0.75 | TP53 (0.44) | MEN1KMT2ARAB9AMAPK1L3MBTL1 | |
| SCHEMBL27662263 | 0.75 | TP53 (0.41) | MEN1KMT2ARAB9AL3MBTL1CYP1A2 | |
| SCHEMBL7440585 | 0.73 | ALPL (0.37) | MEN1KMT2ARAB9AALDH1A1NOTUM | |
| SCHEMBL4243696 | 0.72 | MAP2K3 (0.47) | MEN1KMT2ARAB9AALDH1A1KDM4E | |
| SCHEMBL9521709 | 0.72 | ALDH1A1 (0.41) | MEN1KMT2ARAB9AALDH1A1HPGD | |
| SCHEMBL21336547 | 0.72 | MEN1 (0.38) | MEN1KMT2ARAB9AALDH1A1HPGD | |
| SCHEMBL259469 | 0.72 | GAA (0.51) | KMT2ACYP1A2ALDH1A1HPGDPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |