Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21323158 | 0.85 | TSHR (0.68) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL6836717 | 0.84 | MAPT (0.56) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL25567809 | 0.80 | GRM5 (0.52) | KMT2ATDP1NPC1RAB9APOLB | |
| SCHEMBL8322382 | 0.79 | RAB9A (0.53) | NPC1RAB9APOLBCTNNB1WNT3A | |
| Hydrochloric Acid SCHEMBL27533265 | 0.78 | LMNA (0.46) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL6855344 | 0.77 | ITGB3 (0.48) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| Hydrochloric Acid SCHEMBL6855339 | 0.77 | ITGB3 (0.48) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL3814675 | 0.77 | ATM (0.50) | NPC1RAB9ATSHRPOLBSMN1; SMN2 | |
| SCHEMBL6194884 | 0.77 | RAB9A (0.40) | KMT2ATDP1NPC1RAB9ATSHR | |
| SCHEMBL1115098 | 0.76 | MAPT (0.63) | KMT2ATDP1SLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011091-A1 | TREATMENT OF CANCER, INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES | USHER III INITIATIVE, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |