SCHEMBL1115098

SCHEMBL1115098

O=C(OCc1ccccc1)c1ccc2c(c1)Cc1cc(C(=O)OCc3ccccc3)ccc1-2

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.63
RAB9A P51151 6/20 0.63
ALDH1A1 P00352 5/20 0.63
LMNA P02545 4/20 0.63
NPC1 O15118 4/20 0.63
SMN1; SMN2 Q16637 3/20 0.63
KMT2A Q03164 4/20 0.60
TDP1 Q9NUW8 3/20 0.60
SLC6A2 P23975 1/20 0.60
SLC6A3 Q01959 1/20 0.60
SRD5A2 P31213 2/20 0.54
HPGD P15428 1/20 0.52
SRD5A1 P18405 1/20 0.49
KDM4E B2RXH2 2/20 0.49
CYP1A2 P05177 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
GAA P10253 1/20 0.48
MEN1 O00255 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30935799 1.00 MAPT (0.63) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL22801020 0.82 TDP1 (0.57) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL21027974 0.81 TDP1 (0.51) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL22801022 0.80 KMT2A (0.54) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL26809636 0.80 TDP1 (0.54) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL312287 0.80 KMT2A (0.92) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL6994441 0.79 MAPT (0.60) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL11258682 0.79 MAOA (0.60) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL27359064 0.79 TDP1 (0.53) MAPTRAB9AALDH1A1LMNANPC1
SCHEMBL6002245 0.79 KMT2A (0.70) MAPTRAB9AALDH1A1LMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112839979-B Method for preparing releasable polymeric reagents 尼克塔治疗公司 2024-06-21 CN disclosed
US-11932726-B2 Method of making releasable polymeric reagents NEKTAR THERAPEUTICS (US) 2024-03-19 US disclosed
US-20220143201-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT NEKTAR THERAPEUTICS (US) 2022-05-12 US disclosed
US-11266742-B2 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates NEKTAR THERAPEUTICS (US) 2022-03-08 US disclosed
US-20210388161-A1 METHOD OF MAKING RELEASABLE POLYMERIC REAGENTS NEKTAR THERAPEUTICS 2021-12-16 US disclosed
EP-3864068-A2 METHOD OF MAKING RELEASABLE POLYMERIC REAGENTS Nektar Therapeutics (US) 2021-08-18 EP disclosed
CN-112839979-A Method for preparing releasable polymeric reagents 尼克塔治疗公司 2021-05-25 CN disclosed
US-20200276320-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT NEKTAR THERAPEUTICS (US) 2020-09-03 US disclosed
US-10695435-B2 Composition comprising a polymeric reagent NEKTAR THERAPEUTICS (US) 2020-06-30 US disclosed
US-20190046651-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT NEKTAR THERAPEUTICS 2019-02-14 US disclosed
US-20140107349-A1 Methods for Preparing Polymeric Reagents NEKTAR THERAPEUTICS (US) 2014-04-17 US disclosed
US-20130184443-A1 Methods for Preparing Conjugates NEKTAR THERAPEUTICS (US) 2013-07-18 US disclosed
US-8435505-B2 Pharmaceutical compositions and methods for delivering such compositions NEKTAR THERAPEUTICS (US) 2013-05-07 US disclosed
EP-1896082-B1 CONJUGATES HAVING A DEGRADABLE LINKAGE AND POLYMERIC REAGENTS USEFUL IN PREPARING SUCH CONJUGATES NEKTAR THERAPEUTICS (US) 2012-12-26 EP disclosed
US-20120258912-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR DELIVERING SUCH COMPOSITIONS NEKTAR THERAPEUTICS (US) 2012-10-11 US disclosed
US-8252275-B2 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates NEKTAR THERAPEUTICS (US) 2012-08-28 US disclosed
EP-2279758-A2 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates Nektar Therapeutics (US) 2011-02-02 EP disclosed
EP-1896082-A2 CONJUGATES HAVING A DEGRADABLE LINKAGE AND POLYMERIC REAGENTS USEFUL IN PREPARING SUCH CONJUGATES Nektar Therapeutics AL, Corporation (US) 2008-03-12 EP disclosed
US-20060293499-A1 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates NEKTAR THERAPEUTICS 2006-12-28 US disclosed
WO-2006138572-A2 CONJUGATES HAVING A DEGRADABLE LINKAGE AND POLYMERIC REAGENTS USEFUL IN PREPARING SUCH CONJUGATES NEKTAR THERAPEUTICS AL, CORPORATION (US) 2006-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120258912-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR DELIVERING SUCH COMPOSITIONS ABCG2, SI, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 MAPT 339/4885RAB9A 2000/4885ALDH1A1 1715/4885
US-20220143201-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT CD44, FCGRT, C9 MAPT 1479/4885RAB9A 3754/4885ALDH1A1 898/4885
US-20200276320-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT CD44, FCGRT, C9 MAPT 1479/4885RAB9A 3754/4885ALDH1A1 898/4885
US-11266742-B2 Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates CD44, DNPEP, SI MAPT 1899/4885RAB9A 3259/4885ALDH1A1 492/4885
US-11932726-B2 Method of making releasable polymeric reagents FGB, PCBP1, PFAS MAPT 2710/4885RAB9A 683/4885ALDH1A1 1340/4885
US-20130184443-A1 Methods for Preparing Conjugates SI, CD44, ABCG2 MAPT 731/4885RAB9A 1640/4885ALDH1A1 979/4885
US-20190046651-A1 COMPOSITION COMPRISING A POLYMERIC REAGENT CD44, FCGRT, C9 MAPT 1479/4885RAB9A 3754/4885ALDH1A1 898/4885
US-20210388161-A1 METHOD OF MAKING RELEASABLE POLYMERIC REAGENTS FGB, PCBP1, PFAS MAPT 2710/4885RAB9A 683/4885ALDH1A1 1340/4885
US-10695435-B2 Composition comprising a polymeric reagent CD44, FCGRT, C9 MAPT 1479/4885RAB9A 3754/4885ALDH1A1 898/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.