SCHEMBL7439614

SCHEMBL7439614

O=C(CCC(=O)OCC(Cl)(Cl)Cl)OCC(Cl)(Cl)Cl

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.37
ADRA1A P35348 1/20 0.37
MAPT P10636 1/20 0.36
BLM P54132 1/20 0.36
TSHR P16473 2/20 0.35
POLB P06746 2/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.30
CHRM2 P08172 1/20 0.30
CHRM4 P08173 1/20 0.30
CHRM1 P11229 1/20 0.30
CHRM3 P20309 1/20 0.30
DGKA P23743 1/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4067794 0.91 TSHR (0.33) ADRA2AADRA1AMAPTBLMTSHR
SCHEMBL4075547 0.91 LMNA (0.41) ADRA2AADRA1AMAPTBLMTSHR
SCHEMBL508579 0.90 DGKA (0.41) MAPTTSHRPOLBALDH1A1GAA
SCHEMBL10105403 0.90 TSHR (0.40) MAPTTSHRPOLBALDH1A1DGKA
SCHEMBL8528905 0.89 TSHR (0.56) ADRA2AADRA1AMAPTTSHRPOLB
SCHEMBL9579525 0.87 ALDH1A1 (0.30) POLBALDH1A1
SCHEMBL8944030 0.85 ACE (0.30)
SCHEMBL9481223 0.85
SCHEMBL733969 0.85 ALDH1A1 (0.48) ADRA2AADRA1AMAPTTSHRALDH1A1
SCHEMBL13098016 0.85 KDM4E (0.48) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5733907-A Prodrugs of an inhibitor of HIV protease MERCK & CO., INC. (US) 1998-03-31 US disclosed
EP-0806957-A1 COMBINATION THERAPY FOR HIV INFECTION USING THE HIV PROTEASE INHIBITOR INDINAVIR ADN THE REVERSE TRANSCRIPTASE INHIBITOR 3TC, OPTIONALLY TOGETHER WITH AZT, DDI OR DDC Merck & Co., Inc. (US) 1997-11-19 EP disclosed
EP-0767664-A2 COMBINATION THERAPY FOR HIV INFECTION MERCK & CO. INC. (US) 1997-04-16 EP disclosed
EP-0729467-A1 PRODRUGS OF AN INHIBITOR OF HIV PROTEASE MERCK & CO. INC. (US) 1996-09-04 EP disclosed
WO-1996023509-A1 COMBINATION THERAPY FOR HIV INFECTION USING THE HIV PROTEASE INHIBITOR INDINAVIR AND THE REVERSE TRANSCRIPTASE INHIBITOR 3TC, OPTIONALLY TOGETHER WITH AZT, DDI OR DDC MERCK & CO., INC. (US) 1996-08-08 WO disclosed
WO-1996000068-A2 COMBINATION THERAPY FOR HIV INFECTION MERCK & CO., INC. (US) 1996-01-04 WO disclosed
WO-1995014016-A1 PRODRUGS OF AN INHIBITOR OF HIV PROTEASE MERCK & CO., INC. (US) 1995-05-26 WO disclosed