Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432960 | 0.86 | KCNH2 (0.44) | KDM4EMAPTALDH1A1CCNT1CDK9 | |
| SCHEMBL7439631 | 0.80 | MAPT (0.40) | KDM4EMAPTBLMTDP1ALDH1A1 | |
| SCHEMBL7437559 | 0.76 | KMT2A (0.41) | KDM4EMAPTBLMTDP1ALDH1A1 | |
| SCHEMBL7441183 | 0.74 | LMNA (0.39) | KDM4EMAPTBLMTDP1ALDH1A1 | |
| SCHEMBL7446369 | 0.73 | MEN1 (0.40) | KDM4EMAPTTDP1ALDH1A1POLB | |
| SCHEMBL7428283 | 0.72 | VCP (0.39) | KDM4EMAPTBLMTDP1ALDH1A1 | |
| SCHEMBL7440312 | 0.71 | NCEH1 (0.40) | KDM4EALDH1A1 | |
| SCHEMBL7444737 | 0.71 | PDE3B (0.44) | MAPTALDH1A1APAF1 | |
| SCHEMBL25301661 | 0.70 | EPHX2 (0.48) | KDM4EMAPTTDP1ALDH1A1HPGD | |
| SCHEMBL7412702 | 0.70 | KDM4E (0.44) | KDM4EMAPTBLMTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880817-A | O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |