Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446369 | 0.88 | MEN1 (0.40) | NTSR1SMN1; SMN2DPP4ALDH1A1KDM4E | |
| SCHEMBL7428283 | 0.87 | VCP (0.39) | NTSR1DPP4ALDH1A1KDM4EGAA | |
| SCHEMBL7441183 | 0.85 | LMNA (0.39) | SMN1; SMN2ALDH1A1KDM4ELMNACASP3 | |
| SCHEMBL7444368 | 0.83 | NTSR1 (0.45) | NTSR1SMN1; SMN2LMNACASP3SENP6 | |
| SCHEMBL7443770 | 0.82 | KMT2A (0.47) | NTSR1SMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL7437559 | 0.80 | KMT2A (0.41) | SMN1; SMN2ALDH1A1KDM4ELMNACASP3 | |
| SCHEMBL9830708 | 0.80 | MEN1 (0.44) | NTSR1DPP4ALDH1A1KDM4EGAA | |
| SCHEMBL7439631 | 0.80 | MAPT (0.40) | SMN1; SMN2ALDH1A1KDM4EGAALMNA | |
| SCHEMBL7444737 | 0.79 | PDE3B (0.44) | SMN1; SMN2DPP4ALDH1A1GAALMNA | |
| SCHEMBL7414190 | 0.74 | KDM4E (0.39) | SMN1; SMN2ALDH1A1KDM4EGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880817-A | O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-14 | — | — | US | claimed |