Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 18/20 | 0.43 |
| ▸ | F10 | P00742 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 6/20 | 0.39 |
| ▸ | PLAT | P00750 | 6/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440257 | 1.00 | F2 (0.43) | F2F10ALDH1A1PLGPLAT | |
| SCHEMBL7432914 | 0.99 | F2 (0.42) | F2F10ALDH1A1PLGPLAT | |
| SCHEMBL7448489 | 0.98 | F2 (0.43) | F2F10ALDH1A1PLGPLAT | |
| SCHEMBL7443009 | 0.96 | F2 (0.44) | F2F10ALDH1A1PLGPLAT | |
| SCHEMBL7439956 | 0.91 | PSMB1 (0.41) | F2F10PLGPLATPRSS1 | |
| SCHEMBL7429404 | 0.90 | F2 (0.46) | F2F10PLGPLATPRSS1 | |
| SCHEMBL7443007 | 0.89 | F2 (0.38) | F2F10ALDH1A1PLGPLAT | |
| SCHEMBL7443014 | 0.89 | F2 (0.38) | F2F10ALDH1A1PLGPLAT | |
| SCHEMBL8091462 | 0.88 | F2 (0.50) | F2F10PLGPLATPRSS1 | |
| SCHEMBL8091458 | 0.88 | F2 (0.50) | F2F10PLGPLATPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814622-A | COMPOUND USEFUL AS TRYPSIN LIKE SERINE PROTEASE AS THROMBIN INHIBITORS | ADIR ET COMPAGNIE (FR) | 1998-09-29 | — | — | US | disclosed |