Sugi Predict

Sugi Predict / Compounds / SCHEMBL7440918

SCHEMBL7440918

SCHEMBL7440918

O=C(C1Cc2ccccc2C1)N1CC=C(c2c[nH]c3c(Cl)cccc23)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 12/20 0.46
▸ LMNA P02545 1/20 0.46
▸ TP53 P04637 1/20 0.41
▸ BTK Q06187 2/20 0.41
▸ JAK1 P23458 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ NAMPT P43490 3/20 0.39
▸ CHEK1 O14757 1/20 0.39
▸ ROCK2 O75116 1/20 0.39
▸ RPS6KA5 O75582 1/20 0.39
▸ MAP4K4 O95819 1/20 0.39
▸ CHEK2 O96017 1/20 0.39
▸ PRKCG P05129 1/20 0.39
▸ CDK1 P06493 1/20 0.39
▸ PIM1 P11309 1/20 0.39
▸ FGFR1 P11362 1/20 0.39
▸ PRKACA P17612 1/20 0.39
▸ RPS6KB1 P23443 1/20 0.39
▸ CDK2 P24941 1/20 0.39
▸ MARK3 P27448 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7217262 0.85 LMNA (0.55) MAPTLMNATP53POLB
SCHEMBL27758573 0.84 MAPT (0.48) MAPTLMNATP53BTKPOLB
SCHEMBL16801563 0.83 MAPT (0.50) MAPTLMNATP53BTKPOLB
SCHEMBL7219966 0.82 MAPT (0.51) MAPTLMNATP53POLBHTR1D
SCHEMBL3715280 0.80 PDK4 (0.55) MAPTLMNAJAK1NAMPT
SCHEMBL7214275 0.78 DRD2 (0.47) LMNAHTR1D
SCHEMBL7216904 0.77 MAPT (0.42) MAPTLMNATP53JAK1POLB
SCHEMBL18324889 0.75 LMNA (0.58) MAPTLMNATP53JAK1POLB
SCHEMBL7866280 0.74 SLC6A4 (0.64) LMNAPOLB
SCHEMBL25290977 0.70 KDM4E (0.54) LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946542-B1 INDANE OR DIHYDROINDOLE DERIVATIVES LUNDBECK & CO AS H (DK) 2002-10-09 — — EP disclosed
US-6352988-B2 HIGH AFFINITY FOR D4 RECEPTORS; TREATMENT OF SCHIZOPHRENIA, OTHER PSYCHOSES, ANXIETY DISORDERS, DEPRESSION, ALCOHOL ABUSE, IMPULSE CONTROL DISORDERS, AGGRESSION H. LUNDBECK A/S (DK) 2002-03-05 — — US disclosed
US-20010020095-A1 Indane or dihydroindole derivatives H. LUNDBECK A/S (DK) 2001-09-06 — — US disclosed
US-6262087-B1 HAVE HIGH AFFINITY FOR D4 RECEPTORS; USEFUL IN THE TREATMENT OF CERTAIN PSYCHIATRIC AND NEUROLOGIC DISORDERS, INCLUDING PSYCHOSIS, DEPRESSION AND ANXIETY. H. LUNDBECK A/S (DK) 2001-07-17 — — US disclosed
EP-0946542-A1 INDANE OR DIHYDROINDOLE DERIVATIVES H. LUNDBECK A/S (DK) 1999-10-06 — — EP disclosed
WO-1998028293-A1 INDANE OR DIHYDROINDOLE DERIVATIVES H.LUNDBECK A/S (DK) 1998-07-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010020095-A1 Indane or dihydroindole derivatives HTR4, GPR4, GPR174 MAPT 2009/4885LMNA 4625/4885TP53 2029/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.