Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10599246 | 0.98 | HTT (0.60) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| Oxalic Acid SCHEMBL28342918 | 0.95 | HTT (0.57) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| Sulfuric Acid SCHEMBL7429284 | 0.93 | HTT (0.55) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| Sulfuric Acid SCHEMBL7433922 | 0.89 | HTT (0.51) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| SCHEMBL47346 | 0.84 | HTT (0.66) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| SCHEMBL1446599 | 0.82 | HTT (0.64) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| SCHEMBL10750878 | 0.82 | HTT (0.64) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| SCHEMBL1446597 | 0.82 | HTT (0.64) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| SCHEMBL1446581 | 0.81 | HTT (0.62) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| SCHEMBL17028378 | 0.81 | HTT (0.62) | HTTSMN1; SMN2KMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112898234-A | Preparation method of landiolol hydrochloride intermediate | 天津泰普制药有限公司 | 2021-06-04 | — | — | CN | claimed |
| CN-118754867-A | Synthesis method of landiolol hydrochloride | 伊诺药物研究(南京)有限公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-118598841-A | Preparation method of landiolol hydrochloride | 连云港众维生物医药有限公司 | 2024-09-06 | — | — | CN | disclosed |
| CN-118026960-A | Synthesis method of N- (2-aminoethyl) -4-morpholinecarboxamide oxalate | 深圳市茵诺圣生物科技有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-117865927-A | Preparation method of landiolol hydrochloride and intermediate thereof | 上海新礼泰药业有限公司 | 2024-04-12 | — | — | CN | disclosed |
| US-11173144-B2 | Adrenergic receptor modulating compounds and methods of using the same | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2021-11-16 | — | — | US | disclosed |
| US-11173144-B2 | Adrenergic receptor modulating compounds and methods of using the same | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2021-11-16 | — | — | US | disclosed |
| CN-112898234-A | Preparation method of landiolol hydrochloride intermediate | 天津泰普制药有限公司 | 2021-06-04 | — | — | CN | disclosed |
| US-20200237724-A1 | ADRENERGIC RECEPTOR MODULATING COMPOUNDS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2020-07-30 | — | — | US | disclosed |
| US-20200237724-A1 | ADRENERGIC RECEPTOR MODULATING COMPOUNDS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2020-07-30 | — | — | US | disclosed |
| CN-101768148-A | New preparation method of hydrochloride landiolol | JIE YAN | 2010-07-07 | — | — | CN | disclosed |
| WO-2008083054-A2 | LIGANDS FOR CARDIAC BETA1 ADRENOCEPTOR FOR IMAGING CONGESTIVE HEART FAILURE | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-07-10 | — | — | WO | disclosed |
| EP-0397031-B1 | Novel esters of phenylalkanoic acid | ONO PHARMACEUTICAL CO (JP) | 1994-07-20 | — | — | EP | disclosed |
| US-5013734-A | Treatment Of Cardiovascular Diseases | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-05-07 | — | — | US | disclosed |
| EP-0397031-A1 | Novel esters of phenylalkanoic acid | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-11-14 | — | — | EP | disclosed |
| US-4636501-A | ADRENERGIC BETA BLOCKERS | AKTIEBOLAGET HASSLE (SE) | 1987-01-13 | — | — | US | disclosed |
| EP-0085286-B1 | PARA-SUBSTITUTED 3-PHENOXY-1-CARBONYLAMINOALKYLAMINO-PROPAN-2-OLS HAVING BETA RECEPTOR BLOCKING PROPERTIES | Aktiebolaget Hässle (SE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0085286-A1 | Para-substituted 3-phenoxy-1-carbonylaminoalkylamino-propan-2-ols having beta receptor blocking properties | Aktiebolaget Hässle (SE) | 1983-08-10 | — | — | EP | disclosed |
| US-4172150-A | CARDIOSELECTIVE ADRENERGIC STIMULANTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-10-23 | — | — | US | disclosed |
| US-4143140-A | CARDIO-SELECTIVE B-ADRENERGIC STIMULANT; 1-HYDROXYPHENOXY-3-UREIDOETHYLAMINO-2-PROPANOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200237724-A1 | ADRENERGIC RECEPTOR MODULATING COMPOUNDS AND METHODS OF USING THE SAME | ADRB1, ADRB2, ADRA1B | HTT 3244/4885SMN1; SMN2 2648/4885KMT2A 4787/4885 |
| US-11173144-B2 | Adrenergic receptor modulating compounds and methods of using the same | ADRB1, ADRB2, ADRA1B | HTT 3244/4885SMN1; SMN2 2648/4885KMT2A 4787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.