Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442633 | 0.93 | HTT (0.62) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| Sulfuric Acid SCHEMBL7433922 | 0.92 | HTT (0.51) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10599246 | 0.91 | HTT (0.60) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| Oxalic Acid SCHEMBL28342918 | 0.88 | HTT (0.57) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL47346 | 0.78 | HTT (0.66) | HTTSMN1; SMN2KMT2AMEN1PKM | |
| SCHEMBL1446599 | 0.77 | HTT (0.64) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL10750878 | 0.77 | HTT (0.64) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1446597 | 0.77 | HTT (0.64) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL17028378 | 0.75 | HTT (0.62) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1446581 | 0.75 | HTT (0.62) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112898234-A | Preparation method of landiolol hydrochloride intermediate | 天津泰普制药有限公司 | 2021-06-04 | — | — | CN | disclosed |
| US-9849134-B2 | Method of improving cognition and social behavior in humans having deficits therein due to neurodegenerative disorders and compounds and compositions therefor | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2017-12-26 | — | — | US | disclosed |
| CN-106456649-A | Compounds for improving cognition and social behavior in humans having neurological disorders | 莱兰斯坦福初级大学评议会 | 2017-02-22 | — | — | CN | disclosed |
| EP-3122350-A2 | METHOD OF IMPROVING COGNITION AND SOCIAL BEHAVIOR IN HUMANS HAVING DEFICITS THEREIN DUE TO NEUROLOGICAL DISORDERS AND COMPOUNDS AND COMPOSITIONS THEREFOR | The Board of Trustees of The Leland Stanford Junior University (US) | 2017-02-01 | — | — | EP | disclosed |
| US-20160184315-A1 | METHOD OF IMPROVING COGNITION AND SOCIAL BEHAVIOR IN HUMANS HAVING DEFICITS THEREIN DUE TO NEURODEGENERATIVE DISORDERS AND COMPOUNDS AND COMPOSITIONS THEREFOR | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-06-30 | — | — | US | disclosed |
| WO-2015126915-A2 | METHOD OF IMPROVING COGNITION AND SOCIAL BEHAVIOR IN HUMANS HAVING DEFICITS THEREIN DUE TO NEUROLOGICAL DISORDERS AND COMPOUNDS AND COMPOSITIONS THEREFOR | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-08-27 | — | — | WO | disclosed |
| EP-0307115-A1 | Phenol esters | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-03-15 | — | — | EP | disclosed |
| US-4172150-A | CARDIOSELECTIVE ADRENERGIC STIMULANTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-10-23 | — | — | US | disclosed |
| US-4143140-A | CARDIO-SELECTIVE B-ADRENERGIC STIMULANT; 1-HYDROXYPHENOXY-3-UREIDOETHYLAMINO-2-PROPANOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160184315-A1 | METHOD OF IMPROVING COGNITION AND SOCIAL BEHAVIOR IN HUMANS HAVING DEFICITS THEREIN DUE TO NEURODEGENERATIVE DISORDERS AND COMPOUNDS AND COMPOSITIONS THEREFOR | ADRA1B, ADRB1, ADRA1A | CHRM1 54/4885HTT 816/4885SMN1; SMN2 342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.