Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.45 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967277 | 0.87 | ALDH1A1 (0.54) | AKR1C3AKR1C2AKR1C4AKR1C1ABCB1 | |
| SCHEMBL11026935 | 0.80 | CTSB (0.53) | TSHRAKR1C3AKR1C2AKR1C4AKR1C1 | |
| SCHEMBL6823020 | 0.80 | TPMT (0.58) | TSHRAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL4442629 | 0.78 | CDK2 (0.48) | TSHRAKR1C3AKR1C2AKR1C4AKR1C1 | |
| SCHEMBL14842540 | 0.77 | MCL1 (0.54) | TSHRPKMHPRT1ABCB1ALDH1A1 | |
| SCHEMBL6205105 | 0.77 | ALDH1A1 (0.53) | TSHRAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL669832 | 0.76 | THRB (0.61) | ALDH1A1MAPTHPGDTDP1KDM4E | |
| SCHEMBL976330 | 0.76 | KDM4E (0.57) | PKMALDH1A1MAPTHPGDTDP1 | |
| SCHEMBL485446 | 0.75 | KDM4E (0.47) | ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL6987407 | 0.75 | HSD17B10 (0.56) | ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985895-A | 2-naphthamide derivatives and their therapeutic applications | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-INSERM (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5872119-A | 2-Naphthamide derivatives and their therapeutic applications | Institut National De La Sante et De La Recherche Medicale--INSERM (FR) | 1999-02-16 | — | — | US | disclosed |
| EP-0585116-B1 | 1-Alkoxy-naphthalene-2-carboxamide derivatives with high affinity for the serotonin 5-HT1A receptor | LILLY INDUSTRIES LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5389684-A | Treats disorder of central nervous system | LILLY INDUSTRIES LIMITED (GB) | 1995-02-14 | — | — | US | disclosed |
| EP-0585116-A1 | 1-Alkoxy-naphthalene-2-carboxamide derivatives with high affinity for the serotonin 5-HT1A receptor | LILLY INDUSTRIES LIMITED (GB) | 1994-03-02 | — | — | EP | disclosed |