Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 8/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.40 |
| ▸ | MMP13 | P45452 | 7/20 | 0.38 |
| ▸ | MMP9 | P14780 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 5/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MMP16 | P51512 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446094 | 0.85 | CA1 (0.41) | KEAP1NFE2L2MMP13MMP9MMP1 | |
| SCHEMBL8436167 | 0.73 | MMP13 (0.54) | MMP13MMP9MMP1MMP2MMP8 | |
| SCHEMBL8434431 | 0.70 | CA1 (0.42) | HTTNPSR1KEAP1NFE2L2MMP13 | |
| SCHEMBL7443108 | 0.69 | MMP9 (0.44) | HTTKEAP1NFE2L2MMP13MMP9 | |
| SCHEMBL27489589 | 0.68 | HTT (0.48) | HTTNPSR1MMP13MMP9MMP1 | |
| SCHEMBL7443126 | 0.66 | MMP2 (0.58) | KEAP1NFE2L2MMP13MMP9MMP1 | |
| SCHEMBL7378971 | 0.66 | MMP13 (0.49) | HTTNPSR1KEAP1NFE2L2MMP13 | |
| SCHEMBL2761358 | 0.65 | HTT (0.55) | HTTNPSR1KEAP1NFE2L2MMP13 | |
| SCHEMBL8435825 | 0.65 | MMP13 (0.45) | MMP13MMP9MMP1MMP2MMP8 | |
| SCHEMBL12725103 | 0.63 | PKM (0.61) | MMP13MMP9MMP1MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380219-B1 | FOR THERAPY OF ARTHRITIS, CANCER, TISSUE ULCERATION, RESTENOSIS, PERIDONTAL DISEASE, EPIDERMOLYSIS BULLOSA, SCLERITIS AND OTHER DISEASES CHARACTERIZED BY MATRIX METALLOPROTEINASE ACTIVITY, SEPSIS, SEPTIC SHOCK | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0813520-B1 | ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES | PFIZER (US) | 2001-12-19 | — | — | EP | disclosed |
| US-6147074-A | Arylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 2000-11-14 | — | — | US | disclosed |
| US-5994351-A | Arylsulfonylamino hydroxamic acid derivatives | PFIZER INC. (US) | 1999-11-30 | — | — | US | disclosed |
| US-5863949-A | Arylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 1999-01-26 | — | — | US | disclosed |
| WO-1996027583-A1 | ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1996-09-12 | — | — | WO | disclosed |