Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | BMP1 | P13497 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451514 | 0.88 | ITGB3 (0.55) | ITGB3ITGAVMEN1KMT2ABMP1 | |
| SCHEMBL7445397 | 0.86 | KMT2A (0.52) | ITGB3ITGAVMMELMNAMAPK1 | |
| SCHEMBL7448467 | 0.85 | PDE4A (0.49) | ITGB3ITGAVLMNAMAPK1HTT | |
| SCHEMBL7448898 | 0.84 | ITGB3 (0.47) | ITGB3ITGAVLMNAMAPK1HTT | |
| SCHEMBL7449150 | 0.83 | ITGB3 (0.46) | ITGB3ITGAVLMNAMAPK1HTT | |
| SCHEMBL7446736 | 0.80 | ITGB3 (0.46) | ITGB3ITGAVLMNAMAPK1HTT | |
| SCHEMBL7445017 | 0.79 | ITGB3 (0.48) | ITGB3ITGAVPDE4APDE4BPDE4C | |
| SCHEMBL7446281 | 0.78 | FPR2 (0.45) | ITGB3ITGAVMMEPDE4APDE4B | |
| SCHEMBL7447599 | 0.77 | CA2 (0.44) | ITGB3ITGAVMMELMNAMAPK1 | |
| SCHEMBL4882468 | 0.74 | MMP2 (0.63) | ITGB3ITGAVLMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221888-B1 | ANTIHISTAMINE, ANTIINFLAMMATORY AGENT, AUTOIMMUNE DISEASE, RHEUMATIC DISORDERS | MERCK & CO., INC. | 2001-04-24 | — | — | US | claimed |
| EP-0998282-A4 | SULFONAMIDES AS CELL ADHESION INHIBITORS | MERCK & CO INC (US) | 2000-08-30 | — | — | EP | claimed |
| EP-0998282-A1 | SULFONAMIDES AS CELL ADHESION INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998053818-A1 | SULFONAMIDES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 1998-12-03 | — | — | WO | claimed |