Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448898 | 0.88 | ITGB3 (0.47) | KMT2AMEN1LMNAMAPK1HTT | |
| SCHEMBL7451514 | 0.87 | ITGB3 (0.55) | KMT2AMEN1ITGB3ITGAVALDH1A1 | |
| SCHEMBL7449150 | 0.87 | ITGB3 (0.46) | KMT2AMEN1LMNAMAPK1HTT | |
| SCHEMBL7444233 | 0.86 | ITGB3 (0.47) | KMT2AMEN1LMNAMAPK1HTT | |
| SCHEMBL7448467 | 0.84 | PDE4A (0.49) | KMT2AMEN1LMNAMAPK1HTT | |
| SCHEMBL7446736 | 0.83 | ITGB3 (0.46) | KMT2AMEN1LMNAMAPK1HTT | |
| SCHEMBL7445017 | 0.82 | ITGB3 (0.48) | KMT2AMEN1ITGB3ITGAVPOLB | |
| SCHEMBL7447599 | 0.82 | CA2 (0.44) | KMT2AMEN1LMNAMAPK1HTT | |
| SCHEMBL7446281 | 0.77 | FPR2 (0.45) | ITGB3ITGAVALDH1A1PDE4APDE4B | |
| SCHEMBL4882468 | 0.77 | MMP2 (0.63) | KMT2AMEN1LMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221888-B1 | ANTIHISTAMINE, ANTIINFLAMMATORY AGENT, AUTOIMMUNE DISEASE, RHEUMATIC DISORDERS | MERCK & CO., INC. | 2001-04-24 | — | — | US | claimed |
| EP-0998282-A4 | SULFONAMIDES AS CELL ADHESION INHIBITORS | MERCK & CO INC (US) | 2000-08-30 | — | — | EP | claimed |
| EP-0998282-A1 | SULFONAMIDES AS CELL ADHESION INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998053818-A1 | SULFONAMIDES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 1998-12-03 | — | — | WO | claimed |