Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599235 | 0.69 | NPC1 (0.69) | KMT2APOLBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1492483 | 0.69 | NPC1 (0.69) | KMT2APOLBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7444401 | 0.67 | ALDH1A1 (0.47) | KMT2APOLBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL874261 | 0.67 | NPC1 (0.68) | KMT2APOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11613796 | 0.67 | KMT2A (0.58) | KMT2AALDH1A1SMN1; SMN2HTTNPC1 | |
| SCHEMBL1850889 | 0.67 | KMT2A (0.76) | KMT2APOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29518393 | 0.66 | LTA4H (0.57) | KMT2APOLBALDH1A1NPC1TDP1 | |
| SCHEMBL1851840 | 0.65 | KMT2A (0.73) | KMT2AALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL6559744 | 0.65 | KDM4E (0.68) | KMT2AALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL5217325 | 0.65 | KDM4E (0.68) | KMT2AALDH1A1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5438063-A | Hypotensive agents, cardiac insufficiency, increased intraocular pressure, and CNS disorders | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-08-01 | — | — | US | disclosed |
| EP-0628556-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |