Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 4/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.55 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.46 |
| ▸ | F2 | P00734 | 5/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.45 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | PROC | P04070 | 1/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.42 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1473418 | 0.82 | TRPM5 (0.50) | TRPM5 | |
| SCHEMBL1473306 | 0.80 | SMN1; SMN2 (0.53) | TRPM5 | |
| SCHEMBL178407 | 0.79 | TRPM5 (0.56) | TRPM5 | |
| SCHEMBL22814101 | 0.78 | TRPM5 (0.54) | TRPM5 | |
| SCHEMBL3640996 | 0.77 | TRPM5 (0.46) | TRPM5 | |
| SCHEMBL7167511 | 0.77 | PRSS1 (0.42) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL20843804 | 0.75 | MAOA (0.52) | TRPM5 | |
| SCHEMBL104554 | 0.75 | TRPM5 (0.52) | TRPM5 | |
| SCHEMBL7448685 | 0.75 | SMN1; SMN2 (0.40) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7446567 | 0.74 | TRPM5 (0.51) | TRPM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966454-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037075-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-08-27 | — | — | WO | disclosed |