Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178407 | 0.81 | TRPM5 (0.56) | TRPM5GAAL3MBTL1OPRK1KDM4E | |
| SCHEMBL22814101 | 0.80 | TRPM5 (0.54) | TRPM5GAAL3MBTL1OPRK1ALDH1A1 | |
| SCHEMBL20843804 | 0.78 | MAOA (0.52) | TRPM5GAAL3MBTL1OPRK1KDM4E | |
| SCHEMBL104554 | 0.78 | TRPM5 (0.52) | TRPM5GAAL3MBTL1OPRK1KDM4E | |
| SCHEMBL7442310 | 0.76 | MEN1 (0.62) | GAATBXAS1L3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL7444527 | 0.76 | KCNJ1 (0.46) | GAATBXAS1LOXL2CYP19A1CYP11B1 | |
| SCHEMBL1473418 | 0.75 | TRPM5 (0.50) | TRPM5TBXAS1OPRK1KDM4ECYP1A2 | |
| SCHEMBL7444492 | 0.74 | KLK1 (0.55) | TRPM5 | |
| SCHEMBL1473306 | 0.73 | SMN1; SMN2 (0.53) | TRPM5ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL12498384 | 0.72 | TRPM5 (0.52) | TRPM5OPRK1KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1088702-C | Disubstituted bicyclic heterocycles, their production and use as medicaments | BOEHRINGER INGELHEIM PHARMA (DE) | 2002-08-07 | — | — | CN | disclosed |
| CN-1248251-A | Disubstituted bicyclic heterocycles, their production and use as medicaments | BOEHRINGER INGELHEIM PHARMA (DE) | 2000-03-22 | — | — | CN | disclosed |
| EP-0966454-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037075-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-08-27 | — | — | WO | disclosed |