Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 7/20 | 0.35 |
| ▸ | MAOB | P27338 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437205 | 0.84 | LMNA (0.40) | LMNAHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL7442018 | 0.82 | MAOA (0.44) | LMNAALDH1A1HSD11B1MAOAMAOB | |
| SCHEMBL7442024 | 0.82 | MAOA (0.44) | LMNAALDH1A1HSD11B1MAOAMAOB | |
| SCHEMBL7444026 | 0.79 | MAOA (0.39) | LMNAALDH1A1HSD11B1MAOAMAOB | |
| SCHEMBL7434413 | 0.79 | MAOA (0.39) | LMNAALDH1A1HSD11B1MAOAMAOB | |
| SCHEMBL7433738 | 0.76 | LMNA (0.42) | LMNAHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL7447857 | 0.75 | ALDH1A1 (0.36) | LMNAALDH1A1HSD11B1MAOAMAOB | |
| SCHEMBL7440895 | 0.75 | ALDH1A1 (0.36) | LMNAALDH1A1HSD11B1MAOAMAOB | |
| SCHEMBL27670530 | 0.71 | HSD11B1 (0.40) | ALDH1A1HSD11B1MAOAMAOBMEN1 | |
| SCHEMBL28819418 | 0.70 | LMNA (0.47) | LMNAHTTNPSR1L3MBTL1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641306-A1 | CARBOCYCLIC AND HETEROCYCLIC HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1992021647-A1 | CARBOCYCLIC AND HETEROCYCLIC HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |