Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25080213 | 0.90 | HSD11B1 (0.49) | HSD11B1ALDH1A1OPRM1OPRK1OPRL1 | |
| SCHEMBL16245152 | 0.85 | ALDH1A1 (0.64) | HSD11B1ALDH1A1DRD2HTR2AHTR7 | |
| SCHEMBL29468193 | 0.85 | ALDH1A1 (0.64) | HSD11B1ALDH1A1DRD2HTR2AHTR7 | |
| SCHEMBL26911699 | 0.82 | HSD11B1 (0.53) | HSD11B1SLC6A4DRD2CCR2HTR1A | |
| SCHEMBL4051581 | 0.82 | DRD2 (0.64) | HSD11B1ALDH1A1OPRM1OPRL1SLC6A4 | |
| SCHEMBL25080191 | 0.82 | HSD11B1 (0.46) | HSD11B1ALDH1A1CCR2HTR2AHTR1D | |
| SCHEMBL25080034 | 0.81 | MTNR1A (0.49) | HSD11B1SLC6A4DRD2CCR2HTR1A | |
| SCHEMBL4674153 | 0.81 | HSD11B1 (0.60) | HSD11B1ALDH1A1OPRM1OPRK1OPRL1 | |
| SCHEMBL18324763 | 0.81 | KDM4E (0.69) | HSD11B1ALDH1A1OPRM1OPRK1OPRL1 | |
| SCHEMBL5340537 | 0.79 | HSD11B1 (0.68) | HSD11B1ALDH1A1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |