Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445377 | 0.80 | MAOB (0.44) | PPARGPPARDPPARAALDH1A1MAPT | |
| SCHEMBL7449929 | 0.77 | GABRA1 (0.53) | PPARGPPARDPPARAALDH1A1LMNA | |
| SCHEMBL10269372 | 0.77 | LTA4H (0.44) | PPARGPPARDPPARAALDH1A1LMNA | |
| SCHEMBL16792531 | 0.74 | GAA (0.47) | ALDH1A1MAPTGALR3GAALTA4H | |
| SCHEMBL6062347 | 0.74 | LTA4H (0.48) | PPARGPPARDPPARAALDH1A1LMNA | |
| SCHEMBL13719038 | 0.74 | LTA4H (0.41) | PPARGPPARDPPARAALDH1A1LMNA | |
| SCHEMBL7453695 | 0.73 | POLB (0.49) | PPARGPPARDPPARAALDH1A1HTR1D | |
| SCHEMBL6504953 | 0.73 | GABRA1 (0.47) | ALDH1A1MAPTGAAMAOA | |
| SCHEMBL7447898 | 0.73 | ALDH1A1 (0.46) | PPARGPPARDPPARAALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL2868615 | 0.73 | GAA (0.46) | ALDH1A1MAPTGAALTA4HMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | claimed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | claimed |
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |