Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 15/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 8/20 | 0.45 |
| ▸ | CTSL | P07711 | 7/20 | 0.45 |
| ▸ | CTSB | P07858 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443876 | 0.85 | CTSL (0.48) | CTSSCTSKCTSLCTSB | |
| SCHEMBL22885981 | 0.82 | CTSS (0.57) | CTSSCTSKCTSLCTSB | |
| SCHEMBL13430765 | 0.81 | MAPT (0.54) | CTSSSYKCTSLCTSBMAPT | |
| SCHEMBL29458852 | 0.77 | SYK (0.58) | CTSSSYKCTSKCTSLCTSB | |
| SCHEMBL18662370 | 0.76 | CTSS (0.54) | CTSSCTSKCTSLCTSB | |
| SCHEMBL17275392 | 0.76 | CTSS (0.54) | CTSSCTSKCTSLCTSB | |
| SCHEMBL7894697 | 0.74 | YAP1 (0.47) | CTSSCTSKCTSLCTSBMAPT | |
| SCHEMBL27492185 | 0.74 | YAP1 (0.47) | CTSSCTSKCTSLCTSBMAPT | |
| SCHEMBL29458707 | 0.73 | MAPT (0.62) | CTSSSYKCTSKMAPT | |
| SCHEMBL11639550 | 0.73 | PPARA (0.54) | CTSSSYKCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0886647-B1 | SERINE PROTEASE INHIBITORS | AKZO NOBEL NV (NL) | 2002-07-24 | — | — | EP | disclosed |
| US-6410684-B1 | ENZYME INHIBITOR FOR USE IN THE TREATMENT OF THROMBOSIS | AKZO NOBEL N.V. (NL) | 2002-06-25 | — | — | US | disclosed |
| EP-0886647-A1 | SERINE PROTEASE INHIBITORS | Akzo Nobel N.V. (NL) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997031937-A1 | SERINE PROTEASE INHIBITORS | AKZO NOBEL N.V. (NL) | 1997-09-04 | — | — | WO | disclosed |