Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5535575 | 0.81 | IDO1 (0.35) | LMNANPSR1ALDH1A1KDM4E | |
| SCHEMBL10613009 | 0.70 | — | — | |
| SCHEMBL8389886 | 0.69 | ALDH1A1 (0.33) | ALDH1A1KDM4E | |
| SCHEMBL2551780 | 0.69 | MAOA (0.41) | — | |
| SCHEMBL20561800 | 0.68 | SLC6A2 (0.33) | — | |
| SCHEMBL1441712 | 0.67 | PKM (0.41) | LMNAPKMNPSR1ALDH1A1KDM4E | |
| SCHEMBL4049816 | 0.67 | HTR2A (0.30) | — | |
| SCHEMBL9839124 | 0.65 | — | — | |
| SCHEMBL8164070 | 0.65 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL1486046 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 426 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023221952-A1 | CYCLIC QUATERNARY AMMONIUM SALT COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 宜昌人福药业有限责任公司 | 2023-11-23 | — | — | WO | claimed |
| US-20190070149-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2019-03-07 | — | — | US | claimed |
| US-9328107-B2 | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2016-05-03 | — | — | US | claimed |
| EP-2018371-B1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2015-03-04 | — | — | EP | claimed |
| US-20140235622-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2014-08-21 | — | — | US | claimed |
| US-8350028-B2 | 2-aminoquinolines | HOFMANN-LA ROCHE INC. (US) | 2013-01-08 | — | — | US | claimed |
| US-20120270861-A1 | Primary Amines And Derivatives Thereof As Modulators Of The 5-HT2A Serotonin Receptor Useful For The Treatment Of Disorders Related Thereto | ARENA PHARMACEUTICALS, INC. | 2012-10-25 | — | — | US | claimed |
| US-7989628-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | claimed |
| EP-2268633-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2011-01-05 | — | — | EP | claimed |
| US-20100099875-A1 | NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS | PHOSPHOENIX SARL (FR) | 2010-04-22 | — | — | US | claimed |
| US-4272441-A | CARBAMYLATION, PHOSGENE, ALCOHOL, AMINE | FMC CORPORATION (US) | 1981-06-09 | — | — | US | claimed |
| US-4263318-A | INSECTICIDES | THE REAGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1981-04-21 | — | — | US | claimed |
| US-4261897-A | N-Chlorosulfinylcarbamate esters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1981-04-14 | — | — | US | claimed |
| US-4262015-A | INSECTICIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1981-04-14 | — | — | US | claimed |
| EP-0016590-A1 | N-Sulfinyl carbamates, their use as pesticides, pesticidal compositions containing them, methods of producing them and halosulfinyl carbamates formed during their production | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1980-10-01 | — | — | EP | claimed |
| US-4201786-A | INSECTICIDES, MITICIDES | UNION CARBIDE CORPORATION (US) | 1980-05-06 | — | — | US | claimed |
| US-4122204-A | MITICIDES, INSECTICIDES | UNION CARBIDE CORPORATION (US) | 1978-10-24 | — | — | US | claimed |
| US-4086246-A | REACTION OF PHOSGENE WITH A PHENOL AND PRIMARY AMINE | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA (HU) | 1978-04-25 | — | — | US | claimed |
| US-4006231-A | INSECTICIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1977-02-01 | — | — | US | claimed |
| US-3997549-A | INSECTICIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1976-12-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235622-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR5A, HTR2A, HTR1A | LMNA 2106/4885PKM 3821/4885NPSR1 41/4885 |
| US-20100099875-A1 | NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS | PNP, NANP, PHOSPHO1 | LMNA 4735/4885PKM 446/4885NPSR1 1952/4885 |
| US-20190070149-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HTR5A, HTR2A, HTR1A | LMNA 2106/4885PKM 3821/4885NPSR1 41/4885 |
| US-20120270861-A1 | Primary Amines And Derivatives Thereof As Modulators Of The 5-HT2A Serotonin Receptor Useful For The Treatment Of Disorders Related Thereto | HTR5A, HTR2A, HTR1A | LMNA 2106/4885PKM 3821/4885NPSR1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.