Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 13/20 | 0.44 |
| ▸ | MMP13 | P45452 | 13/20 | 0.44 |
| ▸ | MMP1 | P03956 | 12/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.44 |
| ▸ | NAMPT | P43490 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828604 | 1.00 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7575726 | 0.92 | NAMPT (0.41) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7823959 | 0.91 | MMP9 (0.43) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7566474 | 0.91 | MMP9 (0.43) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7824531 | 0.89 | MMP13 (0.43) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7451074 | 0.89 | MMP13 (0.43) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7444896 | 0.86 | MMP13 (0.55) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7837165 | 0.85 | PTGS2 (0.41) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7439019 | 0.85 | MMP9 (0.57) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7447930 | 0.83 | MMP9 (0.50) | MMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | claimed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | claimed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | claimed |
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |