Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.43 |
| ▸ | MMP13 | P45452 | 15/20 | 0.43 |
| ▸ | MMP1 | P03956 | 14/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 13/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566474 | 1.00 | MMP9 (0.43) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7820315 | 0.93 | MEN1 (0.41) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7828604 | 0.91 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7445487 | 0.91 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7824531 | 0.87 | MMP13 (0.43) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7451074 | 0.87 | MMP13 (0.43) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7444896 | 0.83 | MMP13 (0.55) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7575726 | 0.83 | NAMPT (0.41) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL7837165 | 0.82 | PTGS2 (0.41) | MMP9MMP13MMP1ADAM17KMT2A | |
| SCHEMBL7447930 | 0.82 | MMP9 (0.50) | MMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | claimed |