Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828604 | 0.92 | MMP9 (0.44) | NAMPTMEN1KMT2AMMP1MMP9 | |
| SCHEMBL7445487 | 0.92 | MMP9 (0.44) | NAMPTMEN1KMT2AMMP1MMP9 | |
| SCHEMBL7820315 | 0.90 | MEN1 (0.41) | NAMPTMEN1KMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL7554898 | 0.89 | TRPM8 (0.42) | NAMPTMEN1KMT2ATBXAS1MMP1 | |
| SCHEMBL7510775 | 0.85 | MMP1 (0.47) | TBXAS1LMNASMN1; SMN2MMP1MMP9 | |
| SCHEMBL7511843 | 0.83 | MMP1 (0.49) | TBXAS1MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7823959 | 0.83 | MMP9 (0.43) | NAMPTMEN1KMT2ASMN1; SMN2MMP1 | |
| SCHEMBL7566474 | 0.83 | MMP9 (0.43) | NAMPTMEN1KMT2ASMN1; SMN2MMP1 | |
| SCHEMBL7451074 | 0.83 | MMP13 (0.43) | MEN1KMT2AMMP1MMP9MMP13 | |
| SCHEMBL7824531 | 0.83 | MMP13 (0.43) | MEN1KMT2AMMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |