Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435365 | 0.94 | MTNR1A (0.50) | MTNR1AMAPTMAPK1TDP1CYP19A1 | |
| SCHEMBL7437340 | 0.80 | CA2 (0.42) | CYP19A1GAANPC1RAB9AKMT2A | |
| SCHEMBL1494386 | 0.78 | MAPT (0.48) | MTNR1AMAPTMAPK1TDP1CYP19A1 | |
| SCHEMBL13054558 | 0.77 | GABRA1 (0.50) | MTNR1AMAPTMAPK1TDP1CYP19A1 | |
| SCHEMBL2487394 | 0.76 | CA2 (0.48) | CYP19A1FFAR1NPC1MAOB | |
| SCHEMBL7443159 | 0.76 | CA2 (0.48) | CYP19A1FFAR1NPC1MAOB | |
| SCHEMBL7445875 | 0.76 | SMN1; SMN2 (0.55) | MTNR1AMAPTTDP1GAASMN1; SMN2 | |
| SCHEMBL7434681 | 0.76 | HCRTR2 (0.36) | MAPTTDP1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL7437879 | 0.75 | DAO (0.41) | MAPTALDH1A1FFAR1NPC1RAB9A | |
| SCHEMBL11483282 | 0.75 | SMN1; SMN2 (0.54) | MTNR1AMAPTCYP19A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |