Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.31 |
| ▸ | ITGAL | P20701 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434823 | 0.80 | AR (0.37) | ALDH1A1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7437340 | 0.80 | CA2 (0.42) | KMT2ANPC1RAB9AMAOB | |
| SCHEMBL7443159 | 0.76 | CA2 (0.48) | HCRTR2NPC1MAOB | |
| SCHEMBL2487394 | 0.76 | CA2 (0.48) | HCRTR2NPC1MAOB | |
| SCHEMBL7434686 | 0.76 | NPC1 (0.42) | HCRTR2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7445863 | 0.76 | MTNR1A (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7437879 | 0.75 | DAO (0.41) | HCRTR2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL7436261 | 0.74 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL1299583 | 0.73 | NISCH (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL1299611 | 0.73 | NISCH (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |