Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440239 | 0.80 | PNMT (0.39) | ALDH1A1MAPTHSD17B10HTR6PKM | |
| SCHEMBL7437340 | 0.78 | CA2 (0.42) | NPC1RAB9A | |
| SCHEMBL7437881 | 0.77 | ALDH1A1 (0.49) | DAOFFAR1HCRTR2USP2ALDH1A1 | |
| SCHEMBL16658444 | 0.77 | HTR6 (0.47) | DAOPTGS2FFAR1ALDH1A1MAPT | |
| SCHEMBL16651863 | 0.76 | FFAR1 (0.48) | DAOPTGS2FFAR1ALDH1A1HTR6 | |
| SCHEMBL7436261 | 0.75 | ALDH1A1 (0.32) | ALDH1A1MAPTHSD17B10NPC1RAB9A | |
| SCHEMBL16650080 | 0.75 | HTR6 (0.46) | DAOPTGS2FFAR1ALDH1A1HTR6 | |
| SCHEMBL7443159 | 0.75 | CA2 (0.48) | DAOFFAR1HCRTR2NPC1HTT | |
| SCHEMBL2487394 | 0.75 | CA2 (0.48) | DAOFFAR1HCRTR2NPC1HTT | |
| SCHEMBL7434681 | 0.75 | HCRTR2 (0.36) | HCRTR2ALDH1A1MAPTALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |