Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149057 | 0.81 | GCLC (0.33) | MMP1MMP2CA12CA1CA2 | |
| SCHEMBL3896487 | 0.71 | GRM2 (0.32) | — | |
| SCHEMBL29690413 | 0.69 | FDPS (0.31) | — | |
| SCHEMBL138697 | 0.69 | ALDH1A1 (0.36) | — | |
| SCHEMBL2990247 | 0.68 | MMP1 (0.34) | MMP1MMP2CA12CA1CA2 | |
| SCHEMBL3889930 | 0.68 | MMP8 (0.37) | MMP8 | |
| SCHEMBL6237312 | 0.66 | GCLC (0.33) | — | |
| SCHEMBL138696 | 0.65 | L3MBTL1 (0.32) | — | |
| SCHEMBL5707266 | 0.65 | L3MBTL1 (0.32) | — | |
| SCHEMBL11597691 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5665754-A | Substituted pyrrolidines | GLAXO WELLCOME INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0720600-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008534-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1995-03-30 | — | — | WO | disclosed |