Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450677 | 0.84 | ITGB3 (0.40) | ITGB3ITGA2BF2RALDH1A1KDM4E | |
| SCHEMBL7448756 | 0.82 | GNAO1 (0.38) | ITGB3ITGA2BF2RALDH1A1HTR4 | |
| SCHEMBL7446777 | 0.80 | GNAO1 (0.40) | ITGB3ITGA2BF2RALDH1A1KDM4E | |
| SCHEMBL5213651 | 0.79 | ALDH1A1 (0.37) | ITGB3ITGA2BF2RALDH1A1KDM4E | |
| SCHEMBL7447634 | 0.78 | ITGB3 (0.36) | ITGB3ITGA2BF2RALDH1A1HTR4 | |
| SCHEMBL7447186 | 0.78 | GNAO1 (0.43) | ITGB3ITGA2BF2RALDH1A1KDM4E | |
| SCHEMBL7455215 | 0.77 | GNAO1 (0.47) | ITGB3ITGA2BF2RKDM4EALOX15 | |
| SCHEMBL7446660 | 0.77 | ITGB3 (0.36) | ITGB3ITGA2BF2RALDH1A1HTR4 | |
| SCHEMBL7443444 | 0.76 | ITGB3 (0.35) | ITGB3ITGA2BF2RALDH1A1KDM4E | |
| SCHEMBL6109592 | 0.76 | ITGB3 (0.52) | ITGB3ITGA2BF2RKDM4ETPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-07-04 | — | — | EP | claimed |
| WO-2000015636-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-23 | — | — | WO | claimed |