Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288109 | 0.81 | ACE (0.54) | CTSKSIRT2ACEACE2CTSL | |
| SCHEMBL7288116 | 0.81 | ACE (0.54) | CTSKSIRT2ACEACE2CTSL | |
| SCHEMBL6654285 | 0.80 | ITGB3 (0.41) | CTSKSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL6654073 | 0.79 | CYP3A4 (0.54) | CTSKTDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6988063 | 0.79 | PPARA (0.52) | CTSKMTNR1AMTNR1BACECTSL | |
| SCHEMBL8212610 | 0.78 | PLA2G10 (0.50) | CTSKMTNR1AMTNR1BTDP1SMN1; SMN2 | |
| SCHEMBL6656140 | 0.77 | TAS1R3 (0.43) | TDP1SMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL13541260 | 0.77 | CTSK (0.41) | CTSKMTNR1AMTNR1BTDP1SMN1; SMN2 | |
| SCHEMBL8064065 | 0.77 | PLA2G10 (0.47) | CTSKMTNR1AMTNR1BTDP1SMN1; SMN2 | |
| SCHEMBL14390637 | 0.77 | SMN1; SMN2 (0.45) | CTSKMTNR1AMTNR1BTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |