Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.60 |
| ▸ | DRD3 | P35462 | 7/20 | 0.60 |
| ▸ | DRD2 | P14416 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12628453 | 0.80 | HTR1D (0.45) | DRD4DRD3DRD2MAPK1 | |
| SCHEMBL10668370 | 0.78 | DRD2 (0.62) | DRD4DRD3DRD2MEN1KMT2A | |
| SCHEMBL6365304 | 0.77 | CA12 (0.57) | MEN1KMT2ATDP1MAOACHRM2 | |
| SCHEMBL7434190 | 0.76 | ALDH1A1 (0.56) | DRD4DRD3DRD2MAPK1GAA | |
| SCHEMBL7439974 | 0.76 | LMNA (0.46) | DRD4DRD3DRD2KMT2AMAPK1 | |
| SCHEMBL13717311 | 0.75 | CA12 (0.54) | DRD4DRD3DRD2MAPK1 | |
| SCHEMBL7206828 | 0.75 | DRD2 (1.00) | DRD4DRD3DRD2 | |
| SCHEMBL10838380 | 0.73 | ADRB3 (0.50) | DRD4DRD3MEN1KMT2AMAPK1 | |
| SCHEMBL4107305 | 0.72 | KDM4E (0.66) | MEN1KMT2AMAPK1GAAMAPT | |
| SCHEMBL1801117 | 0.72 | MAPK1 (0.51) | DRD4DRD3MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228880-B1 | PARKINSON*S DISEASE, TOURETTE*S SYNDROME, SCHIZOPHRENIA, ALCOHOLISM, DRUG ABUSE; SIDE EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORP | 2001-05-08 | — | — | US | disclosed |
| EP-1073636-A1 | 4-AMINO-(ETHYLAMINO)-OXINDOLE DOPAMINE AUTORECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999052870-A1 | 4-AMINO-(ETHYLAMINO)-OXINDOLE DOPAMINE AUTORECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |