Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7771748 | 0.81 | HSD17B1 (0.46) | ALDH1A1SMN1; SMN2BRD4 | |
| SCHEMBL5962103 | 0.78 | POLB (0.56) | ALDH1A1EPHX2L3MBTL1POLBKDM4E | |
| SCHEMBL17681670 | 0.77 | PYGL (0.48) | ALDH1A1EPHX2L3MBTL1POLBKDM4E | |
| SCHEMBL2203640 | 0.76 | KIF11 (0.43) | L3MBTL1 | |
| SCHEMBL5831442 | 0.75 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1POLBKDM4ECYP2C19 | |
| SCHEMBL21268326 | 0.74 | EPHX2 (0.38) | ALDH1A1EPHX2L3MBTL1POLBKDM4E | |
| SCHEMBL17681651 | 0.74 | EPHX1 (0.50) | ALDH1A1EPHX2L3MBTL1POLBKDM4E | |
| SCHEMBL7399776 | 0.74 | HDAC1 (0.46) | ALDH1A1L3MBTL1POLBKDM4ECYP2C19 | |
| SCHEMBL17681776 | 0.73 | ALDH1A1 (0.48) | ALDH1A1EPHX2L3MBTL1RECQLCYP1A2 | |
| SCHEMBL17681667 | 0.73 | CNR2 (0.62) | ALDH1A1KDM4ERECQLCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043263-A | (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-03-28 | — | — | US | disclosed |
| WO-1998008844-A1 | THIAZOLE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE-IV | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-03-05 | — | — | WO | disclosed |