Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.49 |
| ▸ | CCKBR | P32239 | 1/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 7/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 7/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 7/20 | 0.46 |
| ▸ | BMP1 | P13497 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | NPY4R | P50391 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10337144 | 0.94 | PTGER4 (0.47) | PTPN1PSMB1PSMB5PSMB2BMP1 | |
| SCHEMBL11012331 | 0.88 | REN (0.51) | PTPN1CCKBRPSMB1PSMB5PSMB2 | |
| SCHEMBL9417215 | 0.85 | ITGB3 (0.49) | PTPN1CCKBRNPY1RNPY2RNPY4R | |
| SCHEMBL7448118 | 0.85 | REN (0.53) | PTPN1CCKBRPSMB1PSMB5PSMB2 | |
| SCHEMBL7441309 | 0.81 | ITGB3 (0.46) | PTPN1CCKBR | |
| SCHEMBL19051462 | 0.81 | BMP1 (0.54) | BMP1 | |
| SCHEMBL8910628 | 0.81 | KMT2A (0.56) | — | |
| SCHEMBL9417356 | 0.81 | HDAC1 (0.56) | HDAC8 | |
| SCHEMBL1661198 | 0.79 | CTSL (0.57) | PTPN1CTSL | |
| SCHEMBL10408619 | 0.78 | MMP1 (0.46) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| US-4845079-A | HYPOTENSIVE, RENIN INHIBITION | ABBOTT LABORATORIES | 1989-07-04 | — | — | US | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |