Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SLC6A12 | P48065 | 5/20 | 0.40 |
| ▸ | SLC6A11 | P48066 | 5/20 | 0.40 |
| ▸ | SLC6A13 | Q9NSD5 | 5/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30337771 | 0.91 | PLG (0.50) | CYP2D6PLGPLATLMNASLC6A12 | |
| SCHEMBL15514529 | 0.91 | PLG (0.50) | CYP2D6PLGPLATLMNASLC6A12 | |
| SCHEMBL6893837 | 0.91 | PLG (0.50) | CYP2D6PLGPLATLMNASLC6A12 | |
| SCHEMBL652967 | 0.89 | SLC6A12 (0.46) | LMNASLC6A12SLC6A11SLC6A13GABRR1 | |
| SCHEMBL12345487 | 0.89 | SLC6A12 (0.46) | LMNASLC6A12SLC6A11SLC6A13GABRR1 | |
| Bicarbonate SCHEMBL25268053 | 0.87 | CYP2D6 (0.48) | CYP2D6PLGPLATLMNAGABRR1 | |
| SCHEMBL3395936 | 0.84 | SLC6A12 (0.38) | CYP2D6SLC6A12SLC6A11SLC6A13GABRR1 | |
| SCHEMBL19650816 | 0.82 | SLC6A12 (0.46) | CYP2D6PLGPLATLMNASLC6A12 | |
| Adipic Acid SCHEMBL5712299 | 0.82 | NFKB1 (0.46) | CYP2D6PLGPLATLMNASLC6A12 | |
| SCHEMBL28103618 | 0.81 | SLC6A12 (0.41) | LMNASLC6A12SLC6A11SLC6A13GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888286-A1 | NOVEL SUBSTITUTED CYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997033858-A1 | NOVEL SUBSTITUTED CYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-09-18 | — | — | WO | claimed |
| EP-0224751-B1 | DIPHOSPHONIC-ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1990-01-24 | — | — | EP | disclosed |
| US-4719203-A | CALCIUM METABOLISM DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1988-01-12 | — | — | US | disclosed |
| EP-0224751-A1 | Diphosphonic-acid derivatives, process for preparing them and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |